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MetabolicLongevityMitochondria
MOTS-c
Mitochondrial-Derived Peptide
Typical Dose
5–15 mg
Route
Injectable
Variants
10mg · 20mg · 40mg
Overview
What is MOTS-c?
MOTS-c is a 16-amino acid peptide encoded in the mitochondrial genome that regulates metabolic homeostasis and insulin sensitivity.
Mechanism of Action
Activates AMPK signaling, enhancing glucose uptake, fatty acid oxidation and mitochondrial biogenesis.
Key Benefits
- Improves insulin sensitivity
- Enhances exercise capacity
- Supports mitochondrial health
- Metabolic resilience
Research Indications
Metabolic dysfunctionMost Effective
Endurance performanceEffective
Longevity researchEffective
Research Protocols
Disclaimer
These are commonly discussed research protocols and not medical advice. Consult a healthcare provider before use.
| Goal | Dose | Frequency | Route |
|---|---|---|---|
| Conservative | 5 mg | 2x weekly | Subcutaneous |
| Standard starting dose | 10 mg | 2x weekly | Subcutaneous |
| Typical maintenance | 10 mg | 3x weekly | Subcutaneous |
| Maximum | 15 mg | 3x weekly | Subcutaneous |
Peptide Interactions
NAD+
Metformin
SS-31
Side Effects & Safety
Common Side Effects
- Mild fatigue first dose
- Injection-site soreness
Safety Guidelines
- For laboratory research use only — not for human consumption
- Store reconstituted vials at 2–8°C, use within 30 days
- Rotate injection sites to avoid local irritation
- Discontinue and consult a clinician if adverse reactions occur
Quality Indicators
- ≥95% purity verified by HPLC
- Third-party tested for sterility
- Lyophilized in sealed multi-dose vial
- Bacteriostatic water reconstitution
- Refrigerated cold-chain shipping
What to Expect
- 1Week 1–2Improved exercise tolerance
- 2Week 3–4Glucose handling improvements
- 3Week 5–8Sustained metabolic gains
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